FISH for MYC amplification and anti‐MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations
Identifieur interne : 004789 ( Main/Exploration ); précédent : 004788; suivant : 004790FISH for MYC amplification and anti‐MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations
Auteurs : Anthony P. Fernandez [États-Unis] ; Yang Sun [États-Unis] ; Raymond R. Tubbs [États-Unis] ; John R. Goldblum [États-Unis] ; Steven D. Billings [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2012-02.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Amplification de gène, Femelle, Humains, Hémangiosarcome (anatomopathologie), Hémangiosarcome (génétique), Hémangiosarcome (métabolisme), Hémangiosarcome (secondaire), Immunohistochimie (), Maladies vasculaires (anatomopathologie), Maladies vasculaires (génétique), Maladies vasculaires (métabolisme), Mâle, Noyau de la cellule (anatomopathologie), Noyau de la cellule (génétique), Noyau de la cellule (métabolisme), Protéines proto-oncogènes c-myc (génétique), Protéines proto-oncogènes c-myc (métabolisme), Régulation de l'expression des gènes tumoraux, Seconde tumeur primitive, Sujet âgé, Technique FISH ().
- MESH :
- anatomopathologie : Hémangiosarcome, Maladies vasculaires, Noyau de la cellule.
- génétique : Hémangiosarcome, Maladies vasculaires, Noyau de la cellule, Protéines proto-oncogènes c-myc.
- métabolisme : Hémangiosarcome, Maladies vasculaires, Noyau de la cellule, Protéines proto-oncogènes c-myc.
- secondaire : Hémangiosarcome.
- Adulte, Adulte d'âge moyen, Amplification de gène, Femelle, Humains, Immunohistochimie, Mâle, Régulation de l'expression des gènes tumoraux, Seconde tumeur primitive, Sujet âgé, Technique FISH.
English descriptors
- KwdEn :
- Adult, Aged, Cell Nucleus (genetics), Cell Nucleus (metabolism), Cell Nucleus (pathology), Female, Gene Amplification, Gene Expression Regulation, Neoplastic, Hemangiosarcoma (genetics), Hemangiosarcoma (metabolism), Hemangiosarcoma (pathology), Hemangiosarcoma (secondary), Humans, Immunohistochemistry (methods), In Situ Hybridization, Fluorescence (methods), Male, Middle Aged, Neoplasms, Second Primary, Proto-Oncogene Proteins c-myc (genetics), Proto-Oncogene Proteins c-myc (metabolism), Vascular Diseases (genetics), Vascular Diseases (metabolism), Vascular Diseases (pathology).
- MESH :
- chemical , genetics : Proto-Oncogene Proteins c-myc.
- genetics : Cell Nucleus, Hemangiosarcoma, Vascular Diseases.
- metabolism : Cell Nucleus, Hemangiosarcoma, Proto-Oncogene Proteins c-myc, Vascular Diseases.
- methods : Immunohistochemistry, In Situ Hybridization, Fluorescence.
- pathology : Cell Nucleus, Hemangiosarcoma, Vascular Diseases.
- secondary : Hemangiosarcoma.
- Adult, Aged, Female, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Neoplasms, Second Primary.
Abstract
Background: Secondary angiosarcoma and benign but microscopically atypical vascular proliferations (herein referred to as atypical vascular lesion or AVL) are rare consequences of radiation therapy and/or chronic lymphedema most commonly seen in breast cancer patients. Differentiating angiosarcoma from AVL can be difficult due to overlapping clinical and microscopic features. Recently, amplification of MYC has been associated with 55–100% of secondary angiosarcomas but is reportedly absent in AVL. We examined a series of secondary angiosarcoma and AVL for MYC amplification by fluorescence in situ hybridization (FISH) and expression by immunohistochemistry to investigate the diagnostic utility for discriminating angiosarcoma from AVL.
Url:
DOI: 10.1111/j.1600-0560.2011.01843.x
Affiliations:
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unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-02">2012-02</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cell Nucleus (genetics)</term><term>Cell Nucleus (metabolism)</term><term>Cell Nucleus (pathology)</term><term>Female</term><term>Gene Amplification</term><term>Gene Expression Regulation, Neoplastic</term><term>Hemangiosarcoma (genetics)</term><term>Hemangiosarcoma (metabolism)</term><term>Hemangiosarcoma (pathology)</term><term>Hemangiosarcoma (secondary)</term><term>Humans</term><term>Immunohistochemistry (methods)</term><term>In Situ Hybridization, Fluorescence (methods)</term><term>Male</term><term>Middle Aged</term><term>Neoplasms, Second Primary</term><term>Proto-Oncogene Proteins c-myc (genetics)</term><term>Proto-Oncogene Proteins c-myc (metabolism)</term><term>Vascular Diseases (genetics)</term><term>Vascular Diseases (metabolism)</term><term>Vascular Diseases (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Amplification de gène</term><term>Femelle</term><term>Humains</term><term>Hémangiosarcome (anatomopathologie)</term><term>Hémangiosarcome (génétique)</term><term>Hémangiosarcome (métabolisme)</term><term>Hémangiosarcome (secondaire)</term><term>Immunohistochimie ()</term><term>Maladies vasculaires (anatomopathologie)</term><term>Maladies vasculaires (génétique)</term><term>Maladies vasculaires (métabolisme)</term><term>Mâle</term><term>Noyau de la cellule (anatomopathologie)</term><term>Noyau de la cellule (génétique)</term><term>Noyau de la cellule (métabolisme)</term><term>Protéines proto-oncogènes c-myc (génétique)</term><term>Protéines proto-oncogènes c-myc (métabolisme)</term><term>Régulation de l'expression des gènes tumoraux</term><term>Seconde tumeur primitive</term><term>Sujet âgé</term><term>Technique FISH ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-myc</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémangiosarcome</term><term>Maladies vasculaires</term><term>Noyau de la cellule</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Nucleus</term><term>Hemangiosarcoma</term><term>Vascular Diseases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémangiosarcome</term><term>Maladies vasculaires</term><term>Noyau de la cellule</term><term>Protéines proto-oncogènes c-myc</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Hemangiosarcoma</term><term>Proto-Oncogene Proteins c-myc</term><term>Vascular Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term><term>In Situ Hybridization, Fluorescence</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hémangiosarcome</term><term>Maladies vasculaires</term><term>Noyau de la cellule</term><term>Protéines proto-oncogènes c-myc</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cell Nucleus</term><term>Hemangiosarcoma</term><term>Vascular Diseases</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Hémangiosarcome</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Hemangiosarcoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Gene Amplification</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasms, Second Primary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Amplification de gène</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Mâle</term><term>Régulation de l'expression des gènes tumoraux</term><term>Seconde tumeur primitive</term><term>Sujet âgé</term><term>Technique FISH</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Secondary angiosarcoma and benign but microscopically atypical vascular proliferations (herein referred to as atypical vascular lesion or AVL) are rare consequences of radiation therapy and/or chronic lymphedema most commonly seen in breast cancer patients. Differentiating angiosarcoma from AVL can be difficult due to overlapping clinical and microscopic features. Recently, amplification of MYC has been associated with 55–100% of secondary angiosarcomas but is reportedly absent in AVL. We examined a series of secondary angiosarcoma and AVL for MYC amplification by fluorescence in situ hybridization (FISH) and expression by immunohistochemistry to investigate the diagnostic utility for discriminating angiosarcoma from AVL.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Fernandez, Anthony P" sort="Fernandez, Anthony P" uniqKey="Fernandez A" first="Anthony P." last="Fernandez">Anthony P. Fernandez</name></region><name sortKey="Billings, Steven D" sort="Billings, Steven D" uniqKey="Billings S" first="Steven D." last="Billings">Steven D. Billings</name><name sortKey="Billings, Steven D" sort="Billings, Steven D" uniqKey="Billings S" first="Steven D." last="Billings">Steven D. Billings</name><name sortKey="Fernandez, Anthony P" sort="Fernandez, Anthony P" uniqKey="Fernandez A" first="Anthony P." last="Fernandez">Anthony P. Fernandez</name><name sortKey="Goldblum, John R" sort="Goldblum, John R" uniqKey="Goldblum J" first="John R." last="Goldblum">John R. Goldblum</name><name sortKey="Sun, Yang" sort="Sun, Yang" uniqKey="Sun Y" first="Yang" last="Sun">Yang Sun</name><name sortKey="Tubbs, Raymond R" sort="Tubbs, Raymond R" uniqKey="Tubbs R" first="Raymond R." last="Tubbs">Raymond R. Tubbs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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